AICAR

Global Peptide Sciences supplies AICAR to laboratories across Australia, supporting studies into AMPK signalling, cellular energy regulation and mitochondrial biogenesis research.

AICAR, also known as acadesine or by its full name 5-Aminoimidazole-4-carboxamide ribonucleoside, is a synthetic nucleoside analogue rather than a true peptide, despite frequently appearing alongside peptides in research catalogues. Once inside the cell, AICAR is converted into ZMP, a molecule that mimics AMP and activates AMP-activated protein kinase, one of the central pathways governing cellular energy balance.

Each batch is produced under controlled manufacturing conditions and undergoes independent laboratory verification, supporting consistent, repeatable results across analytical testing. A Certificate of Analysis is available on request for every order.

What Is AICAR?

Many researchers ask what is AICAR and what is AICAR peptide used for in laboratory settings, given how consistently it appears in metabolic research literature.

AICAR is best understood as one of the earliest and most widely characterised pharmacological activators of AMPK. By elevating intracellular ZMP without changing the actual ATP to AMP ratio, it effectively tricks the cell into behaving as though energy reserves are low, triggering downstream effects such as increased fatty acid oxidation, GLUT4-mediated glucose uptake and PGC-1alpha driven mitochondrial biogenesis. A widely cited rodent study found that AICAR administration alone improved treadmill endurance in untrained mice, a finding that placed the compound at the centre of exercise-mimetic research.

AICAR Benefits Explored in Research

Within controlled laboratory settings, research connected to AICAR benefits commonly looks at areas such as:

• AMPK signalling and cellular energy-sensing research
• Mitochondrial biogenesis pathway studies
• Glucose and lipid metabolism research
• Exercise-mimetic and metabolic adaptation modelling

These points reflect laboratory observation only and are not intended as claims about therapeutic or performance outcomes.

Research Areas of Interest

• Studies into cellular energy homeostasis
• Investigation of fatty acid oxidation pathways
• Comparative research against other metabolic modulators
• Mitochondrial biogenesis and PGC-1alpha signalling research

Product Information

• Compound: AICAR (Acadesine / 5-Aminoimidazole-4-carboxamide ribonucleoside)
• Classification: Synthetic nucleoside, AMPK activator (not a peptide)
• Form: Lyophilised powder
• Purity level: 99% or above (HPLC / MS verified)
• Testing: Independent third-party laboratory verification, CoA available on request
• Storage: Store at -20°C

AICAR Reconstitution

Researchers reconstituting AICAR for laboratory use typically follow standard laboratory protocols for combining lyophilised research compounds with an appropriate sterile diluent prior to further analytical handling. Global Peptide Sciences does not provide reconstitution instructions intended for self-administration, and all reconstitution should be carried out in accordance with your own laboratory’s established procedures and safety documentation.

Why Researchers Study AICAR

Laboratories examining AMPK signalling and metabolic adaptation frequently reference AICAR as one of the foundational tools in this field, given its long history as a direct pharmacological activator of the AMPK pathway. Most of this evidence comes from rodent and in-vitro models rather than human clinical trials, and AICAR has no approved therapeutic use. It is also worth noting that AICAR is listed under the World Anti-Doping Agency’s Prohibited List as a metabolic modulator, a regulatory detail relevant to any research context involving athletes or sporting bodies.

Researchers comparing options across related metabolic and performance-focused compounds can explore the full performance research category for additional research materials.

Buy AICAR in Australia

Researchers looking to buy AICAR Australia can access verified, batch-tested material through Global Peptide Sciences, with independent Certificates of Analysis available for every order.

Laboratories searching for AICAR in Australia, and exploring what does AICAR do within an AMPK-focused study design, can rely on a consistent supply chain backed by HPLC and LC-MS verification. Researchers can review product-specific documentation directly before finalising an order.

Global Peptide Sciences offers consistent quality control at every stage of supply, and researchers can browse the full catalogue to view other research compounds available alongside AICAR.

Research Use Only

This compound is supplied strictly for laboratory research purposes and is not approved for human consumption or therapeutic use.